PEOPLE

教职员工


Fangyi Chen

 

Associate Professor

Acting Chair

0755-88018407

chenfy@sustc.edu.cn

Work experiences
2012.9 – present Associate Professor, Southern University of Science and Technology

2009. 5 – 2012.9 Research Associate/ Engineer, Oregon Health and Science University.
2008. 7 – 2009. 3 Senior System Design Engineer, KLA-Tencor corp. CA
2006. 7 – 2008. 7 Research Associate/ Engineer, Oregon Health and Science University. 
2004.12 – 2006. 7 Postdoctoral research fellow. Oregon Health and Science University.
2004. 1 – 2004. 5  Teaching Assistant, Boston University
2001. 6 – 2003.12 Research Assistant, Boston University 
Education & trainning
Postdoctoral Fellow (2005 - 2006) Oregon Health and Science University
PhD (Jan 2005) in Electrical Engineering Boston University, Boston, MA
Dissertation: A Hydro-mechanical Biomimetic Cochlea: Experiments and Models
MS (July 2000) in Biomedical Engineering, Tsinghua University, Beijing, China
BS (July 1997) in Biomedical Engineering, Tsinghua University, Beijing, China
Journal publications
Ramamoorthy S, Zha D, Chen F, Jacques SL, Wang R, Choudhury N, Nuttall AL, Fridberger A. “Filtering of acoustic signals within the hearing organ. ” J Neurosci. 2014 Jul 2;34(27):9051-8. doi: 10.1523/JNEUROSCI.0722-14.2014. (equally contributed)
Subhash HM, Choudhury N, Chen F, Wang RK, Jacques SL, Nuttall AL. “Depth-resolved dual-beamlet vibrometry based on Fourier domain low coherence interferometry.”J Biomed Opt. 2013;18(3):036003.
Zha D, Chen F*, Ramamoorthy S, Fridberger A, Choudhury N, et al. (2012) In Vivo Outer Hair Cell Length Changes Expose the Active Process in the Cochlea. PLoS ONE 7(4) (Corresponding author)
Chen F, Zha D, Fridberger A, Zheng J, Choudhury N, Jacques SL, Wang RK, Shi X, Nuttall AL.  2011 A differentially amplified motion in the ear for near-threshold sound detection, Nat Neurosci. June 2011. v14: 770-775
Zheng J, Ramamoorthy S, Ren T, He W, Zha D, Chen F, Magnusson A, Nuttall AL, Fridberger A. “Persistence of past stimulations: storing sounds within the inner ear.” Biophys J. 2011 Apr 6;100(7):1627-34.
Mo W., Chen F., Nechiporuk A. and Nicolson T. “Quantification of vestibular-induced eye movements in zebrafish larvae”  BMC Neuroscience 2010, 11:110 (equally contributed)
Choudhury, N., Chen, F., Zheng, J., Nuttall, A.L., and Wang, R.K. “Volumetric imaging of blood flow within cochlea in gerbil in vivo.” IEEE J Sel Top Quantum Electron. 2009 Oct 20;PP(99):1-6.
Chen, F. and Nuttall, A. “Comment on “Measuring power production in the mammalian cochlea” [Curr. Biol. 17, 1340 (2007)] (L)” Journal of Acoustic Society of America Volume 125, Issue 1, pp. 11-14 (2009)
Chen, F., Choudhury, N., Zheng, J., Matthews, S., Nuttall, A. and Jacques, S., “In vivo imaging and low-coherence interferometry of cochlear membrane vibration” Journal of Biomedical Optics. Volume 12, Issue 2. This paper was selected into April 15, 2007 issue of “Virtual Journal of Biological Physics Research”, an on-line collection of papers in biological physics research.
Chen, F., Cohen, H., Kapusta, C., Fortin, J., Bifano, T., Mountain, D., Zosuls, A., and Hubbard, A “A hydro-mechanical biomimetic cochlea: Experiments and models” Journal of Acoustic Society of America Volume 119,  Issue 1, pp. 394-405. This paper was selected into January 15, 2006 issue of “Virtual Journal of Biological Physics Research”, an on-line collection of papers in biological physics research.
Choudhury, N., Song, G., Chen, F., Matthews, S., Tschinkel, T., Zheng, J., Jacques, S., and Nuttall, A.L. “Low  coherence interferometry of cochlear partition,” Hear. Res. 220(1,2), 1–9 (2006).
Proceedings
Fangyi Chen, Tao Wu, Teresa Wilson, Hrebesh Subhash, Irina Omelchenko, Michael Bateschell, Lingyan Wang, John Brigande, Zhi-Gen Jiang, Alfred Nuttall “Expression and function of channelrhodopsin 2 in mouse outer hair cells”Proc. SPIE. 8586, Optogenetics: Optical Methods for Cellular Control 85860I (March 8, 2013)
Sripriya Ramamoorthy, Yuan Zhang, Tracy Petrie, Fangyi Chen, Hrebesh M. Subhash, Niloy Choudhury, Ruikang Wang, Steven L. Jacques, Alfred L. Nuttall “Measurement of in vivo basal-turn vibrations of the organ of Corti using phase-sensitive Fourier domain optical coherence tomography“ Proc. SPIE. 8565, Photonic Therapeutics and Diagnostics IX 85651V (March 8, 2013) doi: 10.1117/12.2009260
Hrebesh M. Subhash, Ruikang K. Wang, Fangyi Chen, Alfred L. Nuttall "Reflective type objective based spectral-domain phase-sensitive optical coherence tomography for high-sensitive structural and functional imaging of cochlear microstructures through intact bone of an excised guinea pig cochlea" Proc. SPIE. 8571: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII  (March 8, 2013)
Fangyi Chen, Dingjun Zha, Anders Fridberger, Jiefu Zheng, Niloy Choudhury, Steven L. Jacques, Ruikang K. Wang, Alfred L. Nuttall “In vivo measurement of differential motion inside the organ of Corti using a low coherence interferometer system”  Proc. SPIE, Vol. 8207 (2012)
Hrebesh M. Subhash, Niloy Choudhury, Steven L. Jacques, Ruikang K. Wang, Fangyi Chen, Dingjun Zha, Alfred L. Nuttall “Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography”  Proc. SPIE, Vol 8213 (2012)
Choudhury, N., Yaguang Zeng, Anders Fridberger, Chen, F., Dingjun Zha, Nuttall, A.L., and Ruikang K. Wang  “Imaging vibration of the cochlear partition of an excised guinea pig cochlea using phase-sensitive Fourier domain optical coherence tomography”  Proc. SPIE, Vol. 7889 (2011);
Chen, F., Zheng, J., Choudhury, N., Jacques, S., and Nuttall, A.L “Organ of Corti micromechanics with local electrical stimulation” In: Concepts and Challenges in the Biophysics of Hearing, Cooper N. and Kemp D. (ed),  Singapore: World Scientific Pr. 2009.
Choudhury, N., Chen, F., Zheng, J., Nuttall, A.L., and Jacques S. “In vivo imaging and vibration measurement of Guinea pig cochlea”  Proc. SPIE, Vol. 6847, 68471V (2008);
Chen, F., Cohen, H. I., Mountain, D., and Hubbard, A., “A hydro-mechanical biomimetic cochlea: experiments and models,” In: Auditory Mechanisms: Processes and Models, Nuttall AF et. al, (ed), Singapore: World Scientific Pr. 2006.
Choudhury, N., Jacques S., Mathew S., Chen, F., Zheng, J., and Nuttall, A.L., “Low Coherence intereferometry of the cochlear partition,” In: Auditory Mechanisms: Processes and Models, Nuttall AF et. al, (ed), Singapore: World Scientific Pr. 2006.
Hubbard A, Mountain D., Chen F., “Time-domain responses from a nonlinear sandwich model of the cochlea”, In: Biophysics of the Cochlea: From Molecule to model, Gummer AW (ed), Singapore: World Scientific Pr. 2002.
Conference presentations
Zha, D., Chen, F., and Nuttall, A.L. Electrically induced outer hair cell motion measured in the in vivo organ of Corti by OCT. Association for Research in Otolaryngology Midwinter Meeting. Baltimore, MD, February 2011.
Jiang, Z.G., Chen, F, Guan, B.-C., Ma, K.-T. 2008. Mathematical modeling of the I/V relation of vascular smooth muscle cells of guinea pig spiral modiolar artery. in 31th Annual Mid-Winter Meeting of Association  for Research in Otolaryngolog Feb., 2008 in Phoenix, AZ
Zheng, J., Chen, F., Choudhury, N., Jacques, S.L., and Nuttall, A.L. Measurement of sound-evoked vibrations in the organ of Corti of living guinea pigs using optical coherence tomography. Society for Neuroscience Annual Meeting. Washington, DC, November 2008. 00141
Chen, F., Choudhury, N., Zheng, J., Nuttall, A., Ren, T., Jacques, S., “In vivo imaging and vibration measurement of organ of Corti using an OCT system” Accepted to Annual Fall Meeting of Biomedical Engineering Society in Los angeles, Califonia, September 2007.
Chen, F., Choudhury, N., Zheng, J., Matthews, S., Nuttall, A., Ren, T., Zou, Y., Jacques, S., “In vivo image and vibration measurement of Guinea pig cochlea and through bone imaging” in 30th Annual Mid-Winter Meeting of Association for Research in Otolaryngology, Feb. 2007, in Denver, CO
Nuttall, A., Zheng, J., Zou, Y., Chen, F., Ren, T., “Nonlinearity of the cochlear microphonic” in 30th Annual Mid-Winter Meeting of Association for Research in Otolaryngology, Feb. 2007, in Denver, CO
Chen F., Choudhury N, Zheng J, Matthews S, Jacques SL, Nuttall AL, “A low-coherence interferometry system and its use for vibration measurement and imaging of the guinea pig organ of Corti in vivo” in 43rd Inner Ear Biology Workshop September 2006 in Montpellier, France
Chen, F., Fortin, J., Zosuls, A., Mountain, D., Bifano, T., and Hubbard, A., “A biomimic hydro-mechanical cochlea: experiments and models,” in Annual Fall Meeting of Biomedical Engineering Society in Philadelphia, Pennsylvania 2004.
Chen F., Fortin, J., Zosuls, A., Mountain, D., Bifano, T., and Hubbard, A., “A life-sized mechanical cochlea: experimental and model data” in Seventh International Conference on Cognitive and Neural Systems in Boston, Massachusetts 2003
Chen F., Xing X., Cohen H., Zosuls A., and Hubbard A., “Results from a 64-channel electronic cochlea chip” in Seventh International Conference on Cognitive and Neural Systems in Boston, Massachusetts 2003
Oral Presentations
“The backward propagation of basilar membrane vibration in a temporal bone preparation” Presented in 29th Annual Mid-Winter Meeting of Association for Research in Otolaryngology, Feb. 2006, in Baltimore, MD.
 “Measuring the backward wave propagation in the cochlea in vivo.” Presented in Association for Research in Otolaryngology Midwinter Meeting. Anaheim, CA, February 2010.

Major Awards
2012           The Recruitment Program of Global Youth Experts, China central government
2005-2006: Postdoctoral Fellow, Cochlear Mechanics Lab, Oregon Hearing Research Center
2003:      Dean’s Award for the best Poster in Science and Technology Day, Boston University
2000-2001: Dean’s Fellowship, College of Engineering, Boston University
Grant awarded

2015 – 2018           Natural Science Foundation of China   PI     ¥730,000
Title: In vivo Measurement of the location and longitudinal distribution of the cochlea amplifier & Study of its generation mechanism
2013-2016  The Recruitment Program of Global Youth Experts PI ¥2,000,000
2013-2016  Startup fund PI ¥5,000,000
2010 - 2011           Deafness Research Foundation research grant PI   $20,000
Membership
2004 – now Member of the Association for Research in Otolaryngology
2007 – 2008 Member of the Biomedical Engineering Society
2010 – now The Society of Photo-optical Instrumentation Engineers (SPIE)


Lab:   http://chenlab.bme.sustc.edu.cn/index.html