PEOPLE

教职员工


Guozhi Xiao

 

Professor

0755-88018488

xiaogz@sustc.edu.cn


,

EDUCATION (教育经历)



UNDERGRADUATE (本科):

Dates Attended Name and Location Degree Received Major Subject

of Institution and Year

Sept, 1979 南昌大学医学院 M.D., July, 1984 Medicine

GRADUATE (研究生):

Dates Attended Name and Location Degree Received Major Subject

of Institution and Year

Sept, 1985 北京大学医学部 M.S., July, 1988 Biochemistry

Sept, 1991 北京大学医学部 Ph.D., June, 1994 Biochemistry &

Molecular Biology

POSTGRADUATE (博士后):

Dates Attended Name and Location Name of Program Director

of Institution and Discipline

July, 1994-Oct, 1995 University of Michigan Dr. Daniel Goldman

Medical School Molecular Neurobiology

Ann Arbor, MI.

Nov, 1995-July, 1998 University of Michigan Dr. Renny T. Franceschi

Dental School Bone Biology

Ann Arbor, MI.

ACADEMIC APPOINTMENTS (工作经历)

Years Inclusive Name and Location Rank/Title

of Institution

Nov, 2015- 南方科技大学生物学 教授, 生物系系主任

May, 2013- 南方科技大学生物学 教授

June, 2012- Rush University Falk Endowed Chair Professor of

Medical Center Biochemistry (冠名讲席教授)

Chicago, IL. Director of Research (科研主任)

Jan, 2012- Rush University Associate Professor (终身)

Medical Center

Chicago, IL.

May, 2011-Dec, 2012 University of Pittsburgh Associate Professor (终身)

Medical School

Pittsburgh, PA.

July, 2005-April 2011 University of Pittsburgh Assistant Professor (tenure track)

Medical School

Pittsburgh, PA.

July, 2004-June, 2005 University of Michigan Research Assistant Professor

Dental School (research track)

Ann Arbor, MI.

July, 1998-June, 2004 University of Michigan Research Investigator

Dental School (equivalent to Instructor)

Ann Arbor, MI.

Sept, 1988-Aug, 1991 北京大学医学部 助教,讲师

HONORS AND AWARDS (获奖)

1982-84:南昌大学医学院 ,优秀医学生

1991 北京大学医学部,优秀教师

1992 北京大学医学部,优秀博士生

1993 北京大学医学部,优秀青年教师

1993 北京大学医学部,优秀博士生

1996 ASBMR (美国骨与矿化研究学会大会) Plenary Poster Award

1998 ASBMR Young Investigator Award

1998 ASBMR Travel Award

1998 NIH fellowship Travel Award

1998 NIH postdoctoral fellowship

1999 NIH postdoctoral fellowship

2009 NIDDK new investigator travel award

2012 北京大学医学部(原北京医科大学)100周年校庆,优秀校友荣誉称号

2013 The Inaugural International Chinese Musculoskeletal Research Society (ICMRS)

Meeting. Suzhou, China, 最佳墙报奖

2014 深圳市孔雀学者

2015 深圳市鹏程学者

SOCIETY MEMBERSHIPS (协会会员)

1994- American Society for Bone and Mineral Research (ASBMR)

2000- International Chinese Hard Tissue Society (ICHTS)

2012- Association for Osteobiology

2013- American Society for Biochemistry and Molecular Biology (ASBMB)

2015- Member, Organization Committee of Regenerative Medicine Group, Chinese Society for Repair

and Constructive Surgery (中国修复重建外科学会再生医学转化组委员)

2015- Member, Academic Committee of Engineering and Technology, China Biomedical Association

(中国生物医学协会工程技术学会委员)

TEACHING (教学)

Courses:

1988: Biochemical Experiments Course for medical students, Peking University, about 20

students, 80 hours.

1989: Advanced Biochemical and Molecular Biological Experiments course for graduate

students, Peking (Beijing) University, about 20 students, 160 hours.

1990: Biochemistry Course for medical students, Peking University, about 150 students, 24

hours.

1991: Biochemistry Course for medical students, Peking University, about 150 students, 24

hours.

1991: Advanced Biochemical and Molecular Biological Experiments course for graduate

students, Peking (Beijing) University, about 20 students, 160 hours.

2004: Course Facilitator for Biochemistry (Case-based study) for dental students, University of

Michigan School of Dentistry.

2009: Angiogenesis: Molecular Pathways and Pathophysiological Functions (Course #: MSCMP

3750) for PhD and MD/PhD students, University of Pittsburgh School of Medicine, Endogenous

angiogenesis inhibitors and integrin signaling (March 2009).

2010: Angiogenesis: Molecular Pathways and Pathophysiological Functions (Course #: MSCMP

3750) for PhD and MD/PhD students, University of Pittsburgh School of Medicine. Osteogenesis

and angiogenesis (March 2010), 15 students, average score: 4.2.

2011: Angiogenesis: Molecular Pathways and Pathophysiological Functions (Course #: MSCMP

3750) for PhD and MD/PhD students, University of Pittsburgh School of Medicine. Osteogenesis

and angiogenesis (March, 2011), 14 students, average score: 4.3.

2012: BCH 581course director (Rush University graduate student course).

2013: BCH 581 course director (Rush University graduate student course).

2014: BCH 571 course (Rush University graduate student course). Osteogenesis and

angiogenesis and related animal models (May 2014).

2015: SUSTC, Biochemistry II

Postdoctoral fellows and students:

Assist Dr. Franceschi with three Ph.D. students and several dental students for their research

projects, University of Michigan School of Dentistry, Ann Arbor, MI (1996-2005)

Ujjal K Singha, PhD, post-doc (2005-2006)

Xiaoyan Zhang, MD, post-doc (2007-2008)

Peter Wang, undergraduate (2009 summer)

Catherine Wu, undergraduate (2008, 2009 and 2010 summer)

Shibing Yu, MD, PhD, post-doc (2006-2010)

Huiling Cao, PhD student (2008-2010)

Shengyong Yang, MD, PhD, post-doc (2009-2011)

Meng Liu, MD, PhD, post-doc (2009-2011)

Hanjie Niu, research assistant (2010-2012)

Sujiu Wang, research assistant (2010-2013)

Xi Zhao, research assistant (2010-2013)

Lu Zheng, PhD student (2008-2013)

Shuai Li, Master’s degree graduate student (2010-2013)

Mo Liu, undergraduate student (2011-2013)

Min Luo, MD, post-doc (2005-2011)

Huiling Cao, PhD, post-doc (2010-2011)

Ke Zhu, PhD student (2009-2013)

Hongli Jiao, PhD, post-doc (2011-2014)

Weimin Deng, MD, PhD, visiting professor (2012-2013)

Wei Zheng, Master’s degree graduate student (2012-2014)

Pingping Song, post-doc (2012-2014)

Xiaobo Li, PhD student (2012-2014)

Lixiao Zhang, Master’s degree graduate student (2012-2015)

Yumei Lai, research associate (2012-)

Ke Zhu, post-doc (2013-)

Yao Chen, research assistant (2014-2015)

Huiling Cao, PhD, instructor (2014-)

Xiao Han, undergraduate student (2014-)

Jingneng Wang, undergraduate student (2014-)

Qingnan Yan, research assistant (2014-)

Chunlei Zhou, post-doc (2015-)

Liting Ma, lab technician (2015-)

Xin Liu, undergraduate student (2015-)

Tianyao Xiao, undergraduate student (2015-)

Yiming Lei, undergraduate student (2015-)

COMMITTEE AND ADMINISTRATIVE SERVICES (委员会成员及行政服务)

2005-2009 Alternate member, Research Safety/Biosafety Committee (IBC), VA Pittsburgh

Healthcare System.

2010 The Competitive Medical Research Fund (CMRF) Review Committee, University

of Pittsburgh School of Medicine.

2009-2011 Voting member, Institutional Biosafety Committee (IBC), VA Pittsburgh

Healthcare System

2009-2011 Internal reviewer, Biomedical Laboratory Research and Development (BLR&D)

Merit Review Application, VA Pittsburgh Healthcare System.

2012 Poster judge, the 29th Annual Rush University Forum for Research and Clinical

Investigation, April 11-12, 2012

2012- Director of Research ( 科研主任) , Department of Biochemistry, Rush

University Medical Center

2012- Director of Bone Histology Core, Department of Biochemistry, Rush University

Medical Center

2012- Organizer of the Joint PI Club meeting – Departments of Anatomy & Cell

Biology and Biochemistry, Rush University Medical Center

2012- Graduate Program Committee Member, Department of Biochemistry, Rush

University Medical Center

2012- Department Advisory Committee Member, Department of Biochemistry, Rush

University Medical Center

2013- Daniel Gorski, PhD thesis advisory committee member, Department of

Biochemistry, Rush University Medical Center

2014- Dapeng Jin, PhD thesis advisory committee chair, Department of Biochemistry,

Rush University Medical Center

Reviewer for Funding Agencies (基金评审)

2008 National Science Foundation: grant reviewer

2009 Reviewer, Biomedical Laboratory Research and Development (BLR&D) Merit

Review Application, VA Pittsburgh Healthcare System.

2009 Italian Ministry of Health (associated with the NIH-CSR): grant reviewer

2010 Italian Ministry of Health (associated with the NIH-CSR): grant reviewer

2010 Reviewer, Biomedical Laboratory Research and Development (BLR&D) Merit

Review Application, VA Pittsburgh Healthcare System.

2010 Study section member, The Competitive Medical Research Fund (CMRF) Review

Committee, University of Pittsburgh School of Medicine.

2011 中国国家自然科学基金委员会医学科学部重点项目二审专家

2011 中国国家自然科学基金委员会医学科学部面上项目二审专家

2011 Reviewer, Biomedical Laboratory Research and Development (BLR&D) Merit

Review Application, VA Pittsburgh Healthcare System.

2012 中国国家自然科学基金委员会医学科学部重点项目一审专家

2012 中国国家自然科学基金委员会医学科学部面上项目一审专家

2012 国家自然科学基金委员会医学科学部国际合作重点项目一审专家

2012 中国国家自然科学基金委员会医学科学部青年项目一审专家

2012 中国国家自然科学基金委员会医学科学部重点项目二审专家

2012 中国国家自然科学基金委员会医学科学部动物模型项目二审专家

2012 中国国家自然科学基金委员会医学科学部面上项目二审专家

2013 Member, RTSC study section (July 12, 2013), Rush University

2013 中国国家自然科学基金委员会生命科学部重点项目一审专家

2013 中国国家自然科学基金委员会医学科学部重点项目一审专家

2013 中国国家自然科学基金委员会医学科学部海外及港澳学者合作研究基金一审

专家

2013 中国国家自然科学基金委员会医学科学部重大国际合作项目一审专家

2014 中国国家自然科学基金委员会生命科学部青年基金项目一审专家

2014 中国国家自然科学基金委员会医学科学部重点项目一审专家

2014 中国国家自然科学基金委员会医学科学部国际(地区)合作与交流项目一审专

2015 中国国家自然科学基金委员会医学科学部重大国际合作项目一审专家

2015 中国国家自然科学基金委员会医学科学部重点项目一审专家

2015 中国国家自然科学基金委员会医学科学部国家杰出青年基金项目一审专家

2015 中国国家自然科学基金委员会医学科学部海外及港澳学者合作研究基金一审

专家

2015 中国国家自然科学基金委员会医学科学部重点项目二审专家

2016 中国国家自然科学基金委员会医学科学部国际合作重点项目中期和结题会议

评审专家

Editorial Board Member (杂志编委会成员):

2009- Journal of Bone and Mineral Research (JBMR) (JCR 一区)

2010- 中国生物化学与分子生物学杂志

2011- Stem Cell Discovery

2013- Journal of Biological Chemistry (JBC) (JCR 一区)

2015- Chinese Journal of Family Planning (中国计划生育学杂志

Reviewer for Professional Journals (专业期刊和会议摘要的审稿人)(34)

Aging Cell

Annals of the Rheumatic Diseases (ARD)

ASBMR (American Society for Bone and Mineral Research) Annual Meeting Abstract reviewer

Bone

Cancer Cell International

Cancer Microenvironment

Cell Proliferation

Cell Report

E-Biomedicine

Endocrinology

European Journal of Oral Sciences

EMBO Journal

Experimental Physiology

FEBS Letters

Gene

International Journal of Biological Sciences

International Journal of Medical Sciences

Journal of Biological Chemistry (JBC)

Journal of Biomedical Materials Research: Part A

Journal of Bone and Mineral Research (JBMR)

Journal of Cellular Biochemistry

Journal of Cellular Physiology

Journal of Dental Research

Journal of Orthopaedic Surgery and Research

Molecular Biology of the Cell (MBC)

Molecular and Cellular Biochemistry

Oncotarget

OncoTargets and Therapy

Plos One

Scientific Reports

Stem Cell Research

Tissue & Cell

Seminars in Cancer Biology

Stem Cells and Development

Oral Presentations at Regional, National, and International Meetings and Invited Seminars

and Lectures(会议口头报告和邀请讲座)

1. Xiao G, Thomas PE, Jiang D, Benson MD, and Franceschi RT. MEK/MAPK activates osteoblast-

specific transcription factor, Osf2/Cbfa1. J. Bone Min. Res. 1998, 13:S5 (ASBMR

Young Investigator Award).

2. Xiao G. MAP kinase pathway activates osteoblast-specific transcription factor, Osf2/Cbfa1.

3rd International Symposium: Molecular Control of Organogenesis. University of Michigan

Ann Arbor, 1999.

3. Xiao G, Thomas PE, Jiang D, Benson MD, and Franceschi RT. MAP kinase activates osteoblast-

specific transcription factor, Osf2/Cbfa1, University of Michigan 1998-99 distinguished

faculty/graduate student seminar series: Joint Colloquium on Regeneration Biology,

1999.

4. Xiao G. A New Mediator of Parathyroid Hormone Actions. CCR Center, University of

Michigan Ann Arbor, 2004.

5. Xiao G. Role of ATF4 Transcription Factor in PTH Actions in Osteoblasts. Center for Bone

Biology, University of Pittsburgh, October 25, 2004.

6. Ge C, Xiao G, Jiang D, and Franceschi RT. Transgenic Modification of MAP Kinase Signaling

in Osteoblasts Leads to Altered Bone Formation and Osteoblast Activity. J. Bone

Min. Res. 2004, 20:1210 (ASBMR Young Investigator Award).

7. Xiao G. Role of ATF4 Transcription Factor In PTH Actions in Osteoblasts. 3rd Annual Research

Symposium, Musculoskeletal Research Center, University of Michigan Ann Arbor.

2004.

8. Ge C, Xiao G, Jiang, D, Franceschi, RT. Interactions between the ERK/MAP Kinase Pathway

and RUNX2 Regulate Skeletal Development. J. Bone Min. Res. 2006, 21:M1145.

9. Xiao G. Role of ATF4 in the Anabolic Action of PTH in Osteoblasts. Chinese Faculty Association

of University of Pittsburgh. May 7, 2006.

10. Lu Y, Cai Z, Xiao G, Yao Z, Anderson JL, Roodman, DG, and Zhang J. Prostate cancer

cells induce osteoclastogenesis and bone resorption through RANKL-independent interleukin-

8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) production. AACR. 2006.

11. Yu S, Luo M, Franceschi RT, Jiang D, Zhang J, Patrene K, Hankenson KD, Roodman GD,

Xiao G. ATF4 Is Required for the Anabolic Actions of PTH on Bone in vivo. J. Bone Min.

Res. 2007, 22:1007.

12. Xiao G. Critical Role of ATF4 in the Anabolic Actions of PTH in Bone. Dept of Physiology

and Pathophysiology, Peking (Beijing) University, Beijing, China. May 7, 2008.

13. Xiao G. ATF4, PTH, and Bone Metabolism. Dept of Immunology, Tianjin Medical University,

Tianjin, China. May 8, 2008.

14. Xiao G. ATF4, A Novel Mediator of PTH Actions in Osteoblasts. Dept of Orthopedics,

Hospital for Special Surgery (HSS), Cornell University Medical School, New York. May

23, 2008.

15. Xiao G. Critical role of activating transcription factor 4 in parathyroid hormone-mediated

bone formation. Military Health Research Forum (MHRF), P25-1, Kansas City, MO, September

2, 2009.

16. Feng, R, Elliot G, Luo M, Lapara MY, Xiao G, Roodman GD, and Lentzsch S. Targeting

CDK4/CDK6 Impairs Osteoclast Progenitor Pool Expansion and Blocks Osteolytic Lesion

Development in Multiple Myeloma, ASH-2009.

17. Xiao G. Molecular mechanism mediating PTH stimulation of bone formation. Workshop on

Opportunities of Joint Health Sciences Research Programs between Chinese Institutions and

University of Pittsburgh, Pittsburgh, Nov 16, 2009.

18. Xiao G. Critical Role of ATF4 in the PTH Actions in Osteoblasts and Bone. Life Science

Institute, Nankai University, Tianjin, Dec 8, 2009.

19. Xiao G. Role of ATF4 in the Actions of PTH in Osteoblasts and Bone. New York University

School of Dentistry, NY, Feb 25, 2010.

20. Xiao G. ATF4 regulates osteoclast differentiation in mice: Nanjing Medical University,

Jiangsu, China, Sept 15, 2010.

21. Xiao G. Molecular control of bone formation and resorption. New York University School

of Dentistry, NY, Nov 1st, 2010.

22. Xiao G. ATF4 regulates osteoclast differentiation: implication in osteolytic bone metastases.

The First International Conference on Tumor Microenvironment, Tianjin, China, July 3,

2010. (Invited speaker).

23. D’Souza S, Jin S, Sammut B, Velu CS, Yu S, Xiao G, Grimes L, Roodman GD, Galson DL.

Multiple Myeloma Cell Induction of GFI-1 in Stromal Cells Suppresses Osteoblast Differentiation

in Patients with Myeloma, J. Bone Min. Res. 2010 (ASBMR Young Investigator

Award).

24. Cao H, Yu S, Yao Z, Galson DL, Jiang Y, Zhang X, Fan J, Lu B, Guan Y, Luo M, Lai Y,

Zhu Y, Kurihara N, Patrene K, Roodman GD, Xiao G. Activating transcription factor 4 controls

osteoclast differentiation. 9th International Conference on Bone and Mineral Research

(ICBMR) & 11th International Osteoporosis Symposium, April 8-12, 2011, Nanjing, China

(ICBMR/IOS Young Investigator Award).

25. Xiao G. Activating transcription factor 4 mediates parathyroid hormone actions in osteoblasts

and bone. 9th International Conference on Bone and Mineral Research (ICBMR) &

11th International Osteoporosis Symposium, April 8-12, 2011, Nanjing China. (Invited

speaker).

26. Cao H, Yu S, Yao Z, Galson DL, Jiang Y, Zhang X, Fan J, Lu B, Guan Y, Luo M, Lai Y,

Kurihara N, Patrene K, Roodman GD, Xiao G. Critical role of ATF4 in regulating osteoclast

differentiation and bone resorption. J. Bone Min. Res. 2011 (ASBMR Young Investigator

Award).

27. Xiao G. ATF4 Regulation of Osteoclast Differentiation and Bone Resorption. Implications

in Myeloma-Induced Osteoclast Activation. Tianjin International Symposium on Myeloma

and the 3rd Hematology Summit Forum of Institute of Hematology and Blood Diseases

Hospital Chinese Academy of Medical Sciences (IHCAMS), Tianjin, China, Oct 15, 2011.

(Invited speaker).

28. Xiao G. ATF4 regulation of osteoclast differentiation. Shihezi University School of Medicine,

Xinjiang, China, July 5, 2011. (Invited speaker).

29. Xiao G. ATF4 Controls Osteoclast Differentiation: Implications in Myeloma Bone Disease.

Rush Medical College, Sept 26, 2011.

30. Xiao G. ATF4 Regulation of Osteoclast Differentiation and Bone Resorption: Implications

in Myeloma Bone Disease. Nanning Medical University, Oct 11, 2011.

31. Xiao G. The Role of ATF4 in Bone. The 29th Annual Rush University Forum for Research

and Clinical Investigation, April 11, 2012.

32. Xiao G. The Role of ATF4 in Bone. Shihezi University School of Medicine, Xinjiang, China,

June 16, 2012. (Invited speaker).

33. Xiao G. The Role of ATF4 in Bone. Department of Orthopaedic Surgery, the University of

Chicago Medical Center, Sept 8, 2012.

34. Xiao G. Regulation of angiogenesis in bone microenvironment. The Second International

Conference on Tumor Microenvironment, Tianjin, China, June 24, 2012. (Invited speaker).

35. Yang X, Li G; Xue G, Xiao G, Chen X, Lu B. ATF4 is induced by ROS and regulates Th1

and Th17 cells. 2013 AAI Annual Meetings.

36. Xiao G. The role of activating transcription factor 4 in bone. The Inaugural International

Chinese Musculoskeletal Research Society (ICMRS) -American Society for Bone and Mineral

Research (ASBMR) International Chinese Musculoskeletal Research Conference (ICMRC),

July, 2013, Suzhou, China (Invited speaker).

37. Cao H, Zhu K, Qiu L, Shuai Li S, Niu H, Yang S, Zhao Z, Hao, M, Anderson JL, Fan J,

Roodman GD, Xiao G. AKT is critical for myeloma promotion of osteoclast differentiation

and osteolytic lesions. The Inaugural International Chinese Musculoskeletal Research Society

(ICMRS) -American Society for Bone and Mineral Research (ASBMR) International

Chinese Musculoskeletal Research Conference (ICMRC), July 2013, Suzhou, China. (Invited

speaker).

38. Xiao G. ATF4 and bone homeostasis. Institute of Hematology and Blood Diseases Hospital,

Chinese Academy of Medical Sciences, Tianjin, China, May 17, 2013 (Invited speaker)

39. Xiao G. Mechanisms of osteoclast activation and osteolysis in myeloma bone disease. 1st

Union International Summit Forum on Lymphoid Malignancies, Oct. 17 to 20, 2013, Tianjin

China (Invited speaker).

40. Xiao G. Kindlin-2 regulation of skeletal development and homeostasis. Institute of Molecular

Medicine and Genetics, Georgia Regents University, Augusta, March 10, 2014. (Invited

speaker).

41. Xiao G. ATF4 controls bone angiogenesis through regulation of VEGF expression and release.

The 12th International Conference on Bone and Mineral Research & 14th International

Osteoporosis Symposium, Hangzhou, April 18 to April 21, 2014. (Invited speaker).

42. Xiao G. Novel roles of cell adhesion protein Kindlin-2 in regulation of skeletal development

and homeostasis. International Symposium on Biomineralization, Chonnam National University,

Gwangju, Korea, June 13, 2014 (本次大会唯一Keynote speaker).

43. Xiao G. Roles of cell adhesion protein Kindlin-2 in regulation of skeletal development and

homeostasis. The Second International