教职员工

PEOPLE


陈放怡

 

副教授

执行系主任

致任书院副院长、第十二届全国青联委员

0755-88018407

chenfy@sustc.edu.cn

个人简介:

陈放怡副教授曾在美国国防部高级研究计划局(DARPA)资助下,设计并研制成功用于智能声学传感器网络的仿生学机械耳蜗原型。这个智能声学传感器不仅提供声传感功能,而且通过模仿耳蜗的功能,以本身的流体力学结构对声音信号进行频谱分析。这个仿生学功能不仅省去了通常系统中复杂的电子频谱分析系统,而且使用的是声音信号本身的能量,节省系统能耗。这个传感器可以运用于军事上作为战场远程声学监控系统以及安装在头盔上的单兵环境监视预警系统的一部分。在民用领域,可以用于对机械装置的无损检测和监控。该成果发表在美国声学学会会刊(JASA)并且被收录在January 15, 2006 issue of “Virtual Journal of Biological Physics Research” 在美国国立卫生研究院(NIH)资助下,研制成功世界首台用于测试内耳Corti器内结构差分运动的低相干干涉仪系统。这项技术是继1991年Heterodyne Interferometer被引入耳蜗动力学研究以后耳蜗动力学领域最重大的技术进步。此项发明分别发表在听觉研究(Hearing Research)和生物医学光学杂志(Journal of Biomedical Optics)并且被收录在April 15, 2007 issue of “Virtual Journal of Biological Physics Research” 在美国国立卫生研究院(NIH)资助下,运用自身研制的低相干干涉仪系统首次在体证明了Corti器内部结构差分运动和外毛细胞的主动运动。不同近三十年来耳蜗微观机械学的离体研究,这项研究首次将耳蜗微观结构作为整体在正常生理状态下进行研究,开启了对耳蜗放大器进行在体研究的大门。本项以及今后的研究将对耳蜗生理学工作原理以及哺乳动物的灵敏听觉以及对频率的极高分辨率的理解提供坚实的实验基础。这一重大发现发表在自然-神经科学杂志(Nat.Neuroscience) 作为PI申请到美国聋病研究基金会(Deafness Research Foundation)研究基金,对耳蜗内部的声波传导途径进行研究。本项研究不仅有助于对于理解耳蜗动力学的基本原理,而且对于临床解释和运用耳声发射进行无损诊断提供理论基础。 在美国国立卫生研究院(NIH)资助下,运用先进的频域低相干成像系统对耳蜗血流进行研究。发表在IEEE J Sel Top Quantum Electron. 这套成像系统不仅用于耳蜗,而且可以被用于对大脑,心脏以及其他器官的血流情况进行无损或者微创检测。这套系统不仅是非常有用的研究工具,还可以发展成有益的临床检测设备。 与霍华德-休斯研究院Nicolson实验室合作,研制成功用于测试被基因调控的斑马鱼前庭功能的数字显微镜系统及图像处理软件。发表在BMC-Neuroscience 这项研究成果以及其它几项未发表的测试系统构成了对斑马鱼这种基因调控的动物模型听觉/平衡行为学的综合测试系统。

 

学习经历:

1992-1997 清华大学生物医学工程 学士

1997-2000 清华大学生物医学工程 硕士

2000-2005 波士顿大学电气及计算机工程 博士

 

工作经历:

2012-现在 南方科技大学 副教授

2009-2012 俄勒冈健康科学大学 研究助理/工程师

2008-2009 KLA-Tencor 公司 高级系统设计工程师

2006-2008 俄勒冈健康科学大学 研究助理/工程师

2005-2006 俄勒冈健康科学大学 博士后

 

获奖:

2012.2 中组部第二批青年千人计划

2003.5 波士顿大学科学日工程院最佳板报奖

 

主要发表文章:

1.Ramamoorthy S, Zha D, Chen F, Jacques SL, Wang R, Choudhury N, Nuttall AL, Fridberger A. “Filtering of acoustic signals within the hearing organ. ” J Neurosci. 2014 Jul 2;34(27):9051-8. doi: 10.1523/JNEUROSCI.0722-14.2014. (equally contributed) 
2.Subhash HM, Choudhury N, Chen F, Wang RK, Jacques SL, Nuttall AL. “Depth-resolved dual-beamlet vibrometry based on Fourier domain low coherence interferometry.”J Biomed Opt. 2013;18(3):036003.
3.Zha D, Chen F*, Ramamoorthy S, Fridberger A, Choudhury N, et al. (2012) In Vivo Outer Hair Cell Length Changes Expose the Active Process in the Cochlea. PLoS ONE 7(4) (Corresponding author)
4.Chen F, Zha D, Fridberger A, Zheng J, Choudhury N, Jacques SL, Wang RK, Shi X, Nuttall AL. 2011 A differentially amplified motion in the ear for near-threshold sound detection, Nat Neurosci. June 2011. v14: 770-775
5.Zheng J, Ramamoorthy S, Ren T, He W, Zha D, Chen F, Magnusson A, Nuttall AL, Fridberger A. “Persistence of past stimulations: storing sounds within the inner ear.” Biophys J. 2011 Apr 6;100(7):1627-34. 
6.Mo W., Chen F., Nechiporuk A. and Nicolson T. “Quantification of vestibular-induced eye movements in zebrafish larvae” BMC Neuroscience 2010, 11:110 (equally contributed)
7.Choudhury, N., Chen, F., Zheng, J., Nuttall, A.L., and Wang, R.K. “Volumetric imaging of blood flow within cochlea in gerbil in vivo.” IEEE J Sel Top Quantum Electron. 2009 Oct 20;PP(99):1-6.
8.Chen, F. and Nuttall, A. “Comment on “Measuring power production in the mammalian cochlea” [Curr. Biol. 17, 1340 (2007)] (L)” Journal of Acoustic Society of America Volume 125, Issue 1, pp. 11-14 (2009) 
9.Chen, F., Choudhury, N., Zheng, J., Matthews, S., Nuttall, A. and Jacques, S., “In vivo imaging and low-coherence interferometry of cochlear membrane vibration” Journal of Biomedical Optics. Volume 12, Issue 2. This paper was selected into April 15, 2007 issue of “Virtual Journal of Biological Physics Research”, an on-line collection of papers in biological physics research. 
10.Chen, F., Cohen, H., Kapusta, C., Fortin, J., Bifano, T., Mountain, D., Zosuls, A., and Hubbard, A “A hydro-mechanical biomimetic cochlea: Experiments and models” Journal of Acoustic Society of America Volume 119, Issue 1, pp. 394-405. This paper was selected into January 15, 2006 issue of “Virtual Journal of Biological Physics Research”, an on-line collection of papers in biological physics research. 
11.Choudhury, N., Song, G., Chen, F., Matthews, S., Tschinkel, T., Zheng, J., Jacques, S., and Nuttall, A.L. “Low coherence interferometry of cochlear partition,” Hear. Res. 220(1,2), 1–9 (2006). 
12.Fangyi Chen, Tao Wu, Teresa Wilson, Hrebesh Subhash, Irina Omelchenko, Michael Bateschell, Lingyan Wang, John Brigande, Zhi-Gen Jiang, Alfred Nuttall “Expression and function of channelrhodopsin 2 in mouse outer hair cells”Proc. SPIE. 8586, Optogenetics: Optical Methods for Cellular Control 85860I (March 8, 2013) 
13.Sripriya Ramamoorthy, Yuan Zhang, Tracy Petrie, Fangyi Chen, Hrebesh M. Subhash, Niloy Choudhury, Ruikang Wang, Steven L. Jacques, Alfred L. Nuttall “Measurement of in vivo basal-turn vibrations of the organ of Corti using phase-sensitive Fourier domain optical coherence tomography“ Proc. SPIE. 8565, Photonic Therapeutics and Diagnostics IX 85651V (March 8, 2013) doi: 10.1117/12.2009260
14.Hrebesh M. Subhash, Ruikang K. Wang, Fangyi Chen, Alfred L. Nuttall "Reflective type objective based spectral-domain phase-sensitive optical coherence tomography for high-sensitive structural and functional imaging of cochlear microstructures through intact bone of an excised guinea pig cochlea" Proc. SPIE. 8571: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII (March 8, 2013)
15.Fangyi Chen, Dingjun Zha, Anders Fridberger, Jiefu Zheng, Niloy Choudhury, Steven L. Jacques, Ruikang K. Wang, Alfred L. Nuttall “In vivo measurement of differential motion inside the organ of Corti using a low coherence interferometer system” Proc. SPIE, Vol. 8207 (2012)
16.Hrebesh M. Subhash, Niloy Choudhury, Steven L. Jacques, Ruikang K. Wang, Fangyi Chen, Dingjun Zha, Alfred L. Nuttall “Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography” Proc. SPIE, Vol 8213 (2012)
17.Choudhury, N., Yaguang Zeng, Anders Fridberger, Chen, F., Dingjun Zha, Nuttall, A.L., and Ruikang K. Wang “Imaging vibration of the cochlear partition of an excised guinea pig cochlea using phase-sensitive Fourier domain optical coherence tomography” Proc. SPIE, Vol. 7889 (2011);
18.Chen, F., Zheng, J., Choudhury, N., Jacques, S., and Nuttall, A.L “Organ of Corti micromechanics with local electrical stimulation” In: Concepts and Challenges in the Biophysics of Hearing, Cooper N. and Kemp D. (ed), Singapore: World Scientific Pr. 2009.
Choudhury, N., Chen, F., Zheng, J., Nuttall, A.L., and Jacques S. “In vivo imaging and vibration measurement of Guinea pig cochlea” Proc. SPIE, Vol. 6847, 68471V (2008); 19.Chen, F., Cohen, H. I., Mountain, D., and Hubbard, A., “A hydro-mechanical biomimetic cochlea: experiments and models,” In: Auditory Mechanisms: Processes and Models, Nuttall AF et. al, (ed), Singapore: World Scientific Pr. 2006. 
20.Choudhury, N., Jacques S., Mathew S., Chen, F., Zheng, J., and Nuttall, A.L., “Low Coherence intereferometry of the cochlear partition,” In: Auditory Mechanisms: Processes and Models, Nuttall AF et. al, (ed), Singapore: World Scientific Pr. 2006. 21.Hubbard A, Mountain D., Chen F., “Time-domain responses from a nonlinear sandwich model of the cochlea”, In: Biophysics of the Cochlea: From Molecule to model, Gummer AW (ed), Singapore: World Scientific Pr. 2002. 
2000-2001: Dean’s Fellowship, College of Engineering, Boston University Choudhury, Ruikang Wang, Steven L. Jacques, Alfred L. Nuttall “Measurement of in vivo basal-turn vibrations of the organ of Corti using phase-sensitive Fourier domain optical coherence tomography“ Proc. SPIE. 8565, Photonic Therapeutics and Diagnostics IX 85651V (March 8, 2013) doi: 10.1117/12.2009260
22.Fangyi Chen, Dingjun Zha, Anders Fridberger, Jiefu Zheng, Niloy Choudhury, Steven L. Jacques, Ruikang K. Wang, Alfred L. Nuttall “In vivo measurement of differential motion inside the organ of Corti using a low coherence interferometer system” Proc. SPIE, Vol. 8207 (2012)
23.Hrebesh M. Subhash, Niloy Choudhury, Steven L. Jacques, Ruikang K. Wang, Fangyi Chen, Dingjun Zha, Alfred L. Nuttall “Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography” Proc. SPIE, Vol 8213 (2012)
24.Choudhury, N., Yaguang Zeng, Anders Fridberger, Chen, F., Dingjun Zha, Nuttall, A.L., and Ruikang K. Wang “Imaging vibration of the cochlear partition of an excised guinea pig cochlea using phase-sensitive Fourier domain optical coherence tomography” Proc. SPIE, Vol. 7889 (2011);
25.Chen, F., Zheng, J., Choudhury, N., Jacques, S., and Nuttall, A.L “Organ of Corti micromechanics with local electrical stimulation” In: Concepts and Challenges in the Biophysics of Hearing, Cooper N. and Kemp D. (ed), Singapore: World Scientific Pr. 2009.
Choudhury, N., Chen, F., Zheng, J., Nuttall, A.L., and Jacques S. “In vivo imaging and vibration measurement of Guinea pig cochlea” Proc. SPIE, Vol. 6847, 68471V (2008); 26.Chen, F., Cohen, H. I., Mountain, D., and Hubbard, A., “A hydro-mechanical biomimetic cochlea: experiments and models,” In: Auditory Mechanisms: Processes and Models, Nuttall AF et. al, (ed), Singapore: World Scientific Pr. 2006. 
27.Choudhury, N., Jacques S., Mathew S., Chen, F., Zheng, J., and Nuttall, A.L., “Low Coherence intereferometry of the cochlear partition,” In: Auditory Mechanisms: Processes and Models, Nuttall AF et. al, (ed), Singapore: World Scientific Pr. 2006. 
28.Hubbard A, Mountain D., Chen F., “Time-domain responses from a nonlinear sandwich model of the cochlea”, In: Biophysics of the Cochlea: From Molecule to model, Gummer AW (ed), Singapore: World Scientific Pr. 2002. 


实验室网页:http://chenlab.bme.sustc.edu.cn/index.html