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勇于冒险 甘于艰苦 乐于和谐

Adventurous Arduous Amiable

郭琼玉

助理教授

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个人简介:
郭琼玉博士注重于高分子生物材料在转化医学方向的研发,将其应用于多个具有挑战性的生物医学课题,在可移植人工角膜、可降解血管支架、记忆性纳米材料、骨修复以及细胞调控等领域里取得了突出的研究成果。相关的一系列科研成果多次发表在Biomaterials, Science Translational Medicine, Journal of Controlled Release, Macromolecules, Journal of Biomedical Materials Research Part A等著名专业高水平杂志上。发表学术论文19篇(SCI-E收录17篇),被引用超过300次。第一作者文章8篇。创新成果被国际同行广泛认可,包括Optics & Photonics News,Extracellular Matrix News,ScienceDaily,AIMBE,Physics News等在内的多家国际知名媒体对创新成果多次详细报道。最近两年内申请和获授美国专利达5项,其中可移植人工角膜的研究成果已经在全球包括美国、中国、日本、韩国、印度和欧洲等多个国家提交了多项专利申请。

 

学习经历:
2004年-2010年 美国凯斯西储大学高分子工程 博士
1999年-2004年 中国科技大学高分子工程 学士

 

工作经历:
2017年-至今 南方科技大学生物医学工程系 助理教授
2016年-2017年 美国里海大学生物工程 研究员
2009年-2016年 美国约翰霍普金斯大学生物医学工程 博士后

 

获奖及荣誉:
2010-2013 美国关节炎基金博士后奖学金
研究兴趣:
郭琼玉博士主要研究方向是开发纳米至微米尺度新型形状记忆性药物释放体系用于肿瘤治疗和组织再生,其目标为从材料、细胞、动物实验多个层面为解决具体的临床问题设计一系列智能材料。

 

代表论文 :
1. Q. Guo, D. Miller, H. An, H. Wang, J. Lopez, D. Lough, L. He and A. Kumar, “Controlled heat stress promotes myofibrillogenesis during myogenesis,” PLoS ONE 11(11) (2016) e0166294.
2. S. Majumdar, Q. Guo, M. Garza-Madrid, X. Calderon-Colon, D. Duan, P. Carbajal, O. Schein, M. Trexler, and J. Elisseeff, “Influence of collagen source on fibrillar architecture and properties of vitrified collagen membranes”, J. Biomed. Mater. Res. Part B. 104B (2016) 300-307.
3. Q Guo, J.P. Mather, P. Yang, M. Boden, and P.T. Mather, “Fabrication of polymeric coatings with controlled microtopographies using an electrospraying technique,” PLoS ONE 10(6) (2015) e0129960.
4. S. Yang,# Q. Guo,# L. Shores, A. Aly, M. Ramakrishnan, G.-H. Kim, Q. Lu, L. Su, G. Zhao, J.H. Elisseeff, “Use of a chondroitin sulfate bioadhesive to enhance integration of bioglass particles for repairing critical-size bone defects,” J. Biomed. Mater. Res. Part A. 103A (2015) 235-242. (#= Co-first author)
5. Q. Guo, J.M. Phillip, S. Majumdar, P. Wu, J. Chen, X. Calderón-Colón, O. Schein, B.J. Smith, M.M. Trexler, D. Wirtz, and J.H. Elisseeff, “Modulation of keratocyte phenotype by collagen fibril nanoarchitecture in membranes for corneal repair,” Biomaterials 34 (2013) 9365-9372.
6. Q. Guo,# X. Wang,# M.W. Tibbitt, K.S. Anseth, D.J. Montell, and J.H. Elisseeff, “Light activated cell migration in synthetic extracellular matrices,” Biomaterials 33 (2012) 8040-8046. (#= Co-first author)
7. Q. Guo, A. Aly, O. Schein, M.M. Trexler, and J.H. Elisseeff, “Moxifloxacin in situ gelling microparticles-bioadhesive delivery system,” Results in Pharma. Sciences 2 (2012) 66-71.
8. A.T. Hillel, S. Unterman, Z. Nahas, B. Reid, J.M. Coburn, J. Axelman, J.J. Chae, Q. Guo, R. Trow, A. Thomas, Z. Hou, S. Lichtsteiner, D. Sutton, C. Matheson, P. Walker, N. David, S. Mori, J.M. Taube, and J.H. Elisseeff, “Photoactivated composite biomaterial for soft tissue restoration in rodents and in human,” Sci. Tranl. Med. 3, 93ra67 (2011) 1-12.
9. Q. Guo, P.T. Knight, J. Wu, and P.T. Mather, “Blends of paclitaxel with POSS-based biodegradable polyurethanes: morphology, miscibility, and specific interactions,” Macromolecules 43 (2010) 4991-4999.
10. Q. Guo, P.T. Knight, and P.T. Mather, “Tailored drug release from biodegradable stent coatings based on hybrid polyurethanes,” J. Control. Release 137 (2009) 224-233.

 

著书章节:
1. Q. Guo, and J.H. Elisseeff, Cartilage Tissue Engineering, in: A. Atala, R. Lanza, J.A. Thomson, R. Nerem (Eds.), Principles of Regenerative Medicine, 2nd Ed, Elsevier, 2011, pp. 981-995.

 

专利申请:
1. Q. Guo, J. Green, R.A. Meyer, C.J. Bishop, A. Kumar, and G.L. Semenza, “Shape memory particles for biomedical uses,” Patent application (WO2016164458A1) filed on April 6, 2016.
2. A. Kumar, D. Lough, C. Madsen, and Q. Guo, “Bone healing, angiogenesis-promoting and vasculogenesis-producing system,” Patent application (WO2016172004) filed on April 15, 2016.
3. J.H. Elisseeff, Q. Guo, and S. Majumdar, “Compositions comprising cyclodextrin incorporated collagen matrices for use in biomedical applications,” Patent application (US20170043021A1) filed on September 10, 2015.
4. J.H. Elisseeff, Q. Guo, S. Majumdar, and A. Singh, “Cornea mimetic biomaterials: vitrified collagen-cyclodextrin implants,” Patent Application (WO2016171745A1) filed on April 24, 2015.
5. M.M. Trexler, J.H. Elisseeff, D.G. Mulreany, Q. Guo, J.L. Breidenich, J.P. Maranchi, J.L. Graham, J.B. Patrone, M.W. Patchan, and X. Calderon-Colon, “Wound healing compositions comprising biocompatible cellulose hydrogel membranes and methods of use thereof,” Approved by USPTO on April 19, 2016. Patent #US9314531B2.

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